Apolipoprotein E Phenotypes and Plasma Lipid and Apolipoprotein E Levels in Young Healthy Subjects
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E phenotypes and plasma lipids in young and middle-aged subjects.
The relationship between apolipoprotein (apo) E phenotypes and the levels of plasma lipid, lipoprotein and apo E in young (mean, 21 years of age) and middle-aged (mean, 49 years of age) subjects was investigated. Apo E phenotypes were determined by a rapid flat gel isoelectric focusing method that we had developed previously. Young subjects with apo E3/2 and E4/3 had significantly higher levels...
متن کاملPhenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.
Apolipoprotein (apo) E and the two B apolipoproteins, apoB48 and apoB100, are important proteins in human lipoprotein metabolism. Commonly occurring polymorphisms in the genes for apoE and apoB result in amino acid substitutions that produce readily detectable phenotypic differences in these proteins. We studied changes in apoE and apoB phenotypes before and after liver transplantation to gain ...
متن کاملApolipoprotein E and atherosclerosis: beyond lipid effect.
In humans, apolipoprotein E (apoE) is a polymorphic multifunctional protein.1 It is coded by three alleles ( 2, 3, 4) of a modulator gene (level, variability, and susceptibility gene) at the apoE locus on chromosome 19, determining six apoE genotypes and plasma phenotypes. Its pleiotropic effects are exerted on plasma lipoprotein metabolism, coagulation, oxidative processes, macrophage, glial c...
متن کاملApolipoprotein E in cerebrospinal fluid: relation to phenotype and plasma apolipoprotein E concentrations.
BACKGROUND Apolipoprotein (apo) E may be related to the development of Alzheimer disease, but data on apoE in cerebrospinal fluid (CSF) are limited. The aim of the present study was to measure apoE in CSF and relate its concentrations to apoE phenotype and CSF lipids. METHODS We adapted an assay for CSF apoE sensitivity using an ELISA. It allowed us to measure CSF apoE with sufficient reprodu...
متن کاملApolipoprotein E polymorphism affects plasma levels of lipoprotein(a).
In a group of 303 healthy Caucasian adults of both sexes we studied the influence of the apolipoprotein E (apo E) polymorphism on plasma levels of Lipoprotein(a) (Lp(a). The APOE*2 allele was found to decrease the mean plasma Lp(a) level by 24.8%, whereas the APOE*4 allele increased the mean Lp(a) level by 25.7%. These effects were parallel to the effect of apo E polymorphism on plasma choleste...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1985
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.13.4_849